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New Education and Heritage Centre Proposal
[ 30 August 2013 ]

Indian Orthopaedic Association 57th Annual Conference 2012
[ 16 January 2013 ]

International Revision Hip Arthroplasty Symposium November 2012
[ 30 November 2012 ]

Tim Board
[ 29 May 2018 ]

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[ 30 August 2013 ]

Which factors determine the wear rate of large-diameter metal-on-metal hip replacements? Multivariate analysis of two hundred and seventy-six components.
[ 12 July 2013 ]

Medical management of osteonecrosis of the hip: a review
[ 12 July 2013 ]

New Research Published: Strain imparted during impaction grafting may contribute to bony incorporation:

Board TN, Rooney P, Kay PR.
Strain imparted during impaction grafting may contribute to bony incorporation: AN IN VITRO STUDY OF THE RELEASE OF BMP-7 FROM ALLOGRAFT.

J Bone Joint Surg Br. 2008 Jun;90(6):821-4.

The Centre for Hip Surgery Wrightington Hospital, Appley Bridge, Wigan WN6 9EP, UK.

link to full text article

In order to investigate the osteoinductive properties of allograft used in impaction grafting and the effect of strain during impaction on these properties, we designed an in vitro experiment to measure strain-related release of bone morphogenetic protein-7 (BMP-7) from fresh-frozen femoral head allograft. A total of 40 10 mm cubes of cancellous bone were cut from ten samples of fresh-frozen femoral head. The marrow was removed from the cubes and the baseline concentrations of BMP-7 were measured. Specimens from each femoral head were allocated to four groups and subjected to different compressive strains with a material testing machine, after which BMP-7 activity was reassessed. It was present in all groups. There was a linear increase of 102.1 pg/g (95% confidence interval 68.6 to 135.6) BMP-7 for each 10% increase in strain. At 80% strain the mean concentration of BMP-7 released (830.3 pg/g bone) was approximately four times that released at 20% strain. Activity of BMP-7 in fresh-frozen allograft has not previously been demonstrated. This study shows that the freezing and storage of femoral heads allows some maintenance of biological activity, and that impaction grafting provides a source of osteoinductive bone for remodelling. We have shown that BMP-7 is released from fresh-frozen femoral head cancellous bone in proportion to the strain applied to the bone. This suggests that the impaction process itself may contribute to the biological process of remodelling and bony incorporation.

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